Modified Surface Relief Layer Created by Holographic Lithography: Application to Selective Sodium and Potassium Sensing

Modified Surface Relief Layer Created by Holographic Lithography: Application to Selective Sodium and Potassium Sensing

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Point-of-care diagnostics will rely upon the development of low-cost, noncomplex, and easily integrated systems in order to examine biological samples such as blood and urine obtained from the patient.The development of metal ion sensors is a subject of significant relevance for physiological samples.The level of different blood electrolytes, mainly H+, Na+, K+ and Cl− is considerably used to monitor irregular physiologies.

The particular challenge in biosensing, read more and in fact for any other sensor, is signal differentiation between non-specifically bound material and the specific detecting of the target molecule/ion.The biosensors described in this paper are fabricated by a holographic recording of surface relief structures in a photopolymer material.The surface structures are modified by coating with either dibenzo-18-crown-6 (DC) or tetraethyl 4-tert-butylcalix[4]arene (TBC), which are embedded in a polymer matrix.

Interrogation of these structures by light koip share price allows indirect measurement of the concentration of the analyte.The influence of polymer matrices with different porosities, plasticised polyvinyl chloride (PVC) and a sol-gel matrix, on the performance of the sensors for detection of K+ and Na+ is examined.Here we demonstrate a proof of concept that by using a matrix with higher porosity one can increase the sensitivity of the sensor.

The results showed that the DC sensing layer provides a selective response to K+ over Na+ and the TBC modified grating is more responsive to Na+ over K+.The sensor responds to K+ and Na+ within the physiological concentration ranges.